k-ras inhibitor — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6556	K-Ras(G12C) inhibitor 9		Raf
	K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).		Raf
T3725	K-Ras(G12C) Inhibitor 6		Raf
	K-Ras(G12C) inhibitor 6 is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant that causes 100% modification of the protein when used at 10 μM for 24 hours in vitro.		Raf
T6555	K-Ras(G12C) inhibitor 12		Apoptosis , Raf , Ras
	K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C).		Apoptosis , Raf , Ras
T5469	K-Ras-IN-1		Raf , Ras
	K-Ras-IN-1 is a K-Ras inhibitor.		Raf , Ras
T11738	K-Ras G12C-IN-4		Ras
	K-Ras G12C-IN-4, is a potent Covalent Inhibitor of KRASG12C..		Ras
T8659	K-Ras-PDEδ-IN-1		PDE
	K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ.It binds to the farnesyl binding pocket of PDEδ(Kd of 8 nM).		PDE
T2678	LB42708		Transferase
	LB42708 is an orally active farnesyltransferase (FTase) inhibitor (IC50: 0.8/1.2/2.0 nM toward H/N/K-ras).		Transferase
T38050	CP-609754		Transferase
	CP-609754 (LNK-754) is a potent and reversible farnesyltransferase inhibitor with potential anticancer activity.The IC50 for inhibiting farnesylation of recombinant human H-Ras is 0.57 ng/mL and recombinant K-Ras is 46 n...		Transferase
T1931	6H05	K-Ras inhibitor	Raf , Ras
	6H05 (K-Ras inhibitor) is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).		Raf , Ras
T10375	ARS-1323		Ras
	ARS-1323 is the racemate of ARS-1620 and a mutant K-ras G12C inhibitor.		Ras
T6302	Lonafarnib	Sarasar,Sch66336	Raf , Transferase , Autophagy , Ras
	Lonafarnib (Sch66336) is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B, and N-ras (IC50: 1.9/5.2/2.8 nM).		Raf , Transferase , Autophagy , Ras
T7326	6H05 (TFA)	6H05 TFA,6H05 trifluoroacetate	Ras
	6H05 TFA (6H05 trifluoroacetate) is a selective, and allosteric oncogenic mutant K-Ras(G12C) inhibitor.		Ras
T10376	ARS-1630		Ras
	ARS-1630 is a mutant K-ras G12C inhibitor. It is a less active enantiomer of ARS-1620.		Ras
T8006	Oncrasin-1		Apoptosis , Raf , Ras
	Oncrasin 1 is a potent inhibitor of anticancer that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations		Apoptosis , Raf , Ras
T7414	ARS-853		Apoptosis , Raf , Ras
	ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM), a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cells		Apoptosis , Raf , Ras
T2700	FTI-277 hydrochloride	FTI 277 HCl	Apoptosis , Transferase , Ras
	FTI-277 hydrochloride (FTI 277 HCl) is an effective and specific farnesyltransferase (FTase) inhibitor (IC50: 500 pM); this selectivity is about 100-fold than the closely related GGTase I.		Apoptosis , Transferase , Ras
T11735	K-Ras G12C-IN-1		Phosphatase
	K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C.		Phosphatase
T11737	K-Ras G12C-IN-3		Others
	Heterocyclic compounds as covalent inhibitors of G12C mutant K-Ras protein useful for treating cancers.K-Ras G12C-IN-3 is a novel and irreversible inhibitor of mutant K-ras G12C.		Others
T11736	K-Ras G12C-IN-2		Others
	K-Ras G12C-IN-2 is a covalent kras g12c inhibitor.		Others
T69710	LB42908
	LB42908 is a highly potent Ras farnesyltransferase inhibitor(IC(50)=0.9 nM against H-Ras and 2.4 nM against K-Ras) with potential anticancer activity.